Tuesday, January 14, 2025
Pre-meeting workshop: Bacterial Genomics
10:30-11:15 Strain-Level Characterization of Metagenomic Sequencing Data
Todd Treangen, PhD, Rice University
11:15-11:45 Interactive Demo
11:45-12:00 Q&A
Day 1 – Wednesday, January 15, 2025
Drug Discovery and Mechanisms of Resistance
7:00-8:30 Registration
7:30-8:25 Career Mentoring Panel-Event Hall
Rina Matsuda, Baylor College of Medicine
Dan Kirienko, Rice University
Nancy Ernst, NIAID
Hannah Wilson, CellChorus
8:30-8:35 Welcome
Natasha Kirienko, PhD, Rice University, Houston, TX
Cesar A. Arias, MD, PhD, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
Suzanne Tomlinson-Mathis, PhD, MBA, Gulf Coast Consortia
Session 1 Non-traditional Approaches in Combating AMR-resistant Bacteria
Convener: Natasha Kirienko, PhD, Rice University, Houston, TX
8:35-8:55 Bactericidal Monoclonal Antibodies Against Lipopolysaccharide Protect Against Pseudomonas Aeruginosa Challenge in Mice
Mariette Barbier, PhD, West Virginia University, WV
8:55-9:15 In Situ Microbiome Engineering Using RNA-Based Technologies
James Chappell, PhD
Rice University, Houston, TX
9:15-9:35 Derivatives of Enterococcal Peptide EntV as a Novel Antifungal
Danielle Garsin, PhD, UT Health, Houston, TX
9:35-10:05 Vendor Show and Networking-Pre-function and Event Hall
Session 2 T32 Trainee Symposium: Texas Medical Center Training Program on Antimicrobial Resistance (TP-AMR), Emory Training Program on Antimicrobial Resistance, University of Pittsburgh Training Program on Antimicrobial Resistance
Conveners: Alex Kang, PhD, Houston Methodist Research Institute, Houston, TX
Taylor Blackburn, Emory University, Atlanta, GA
10:05-10:20 Levering Human Microbiomes for Infectious Disease Prediction and Treatment
Henok Tegegne, PhD, Baylor College of Medicine, Houston, TX
10:20-10:35 RND-Type Efflux Pumps in P. Aeruginosa
Mina Henes
Emory University, Atlanta, GA
10:35-10:50 Mitigating the Spread of Antimicrobial Resistance in Healthcare Settings through Real-time Genomic Surveillance of Bacterial Plasmids
Nathan Raabe, University of Pittsburgh, Pittsburgh, PA
Session 3 Barbara E. Murray Keynote Lecture
Conveners: Cesar A. Arias, MD, PhD, Houston Methodist Research Institute
Anna Konovalova, PhD, University of Texas Health Science Center Houston
10:50-10:55 Legacy of Barbara Murray
Cesar A. Arias, MD, PhD, Houston Methodist Research Institute
10:55-11:00 Introduction of the Keynote speaker
Anna Konovalova, University of Texas Health Science Center Houston
11:00-11:30 New Developments in Assembly of the Staphylococcal Cell Envelope
Suzanne Walker, PhD, Harvard University, Cambridge MA
11:30-1:45 Lunch/Rapid Fire/Poster Session-Event Hall
11:30-12:15 Lunch
12:15-12:45 Rapid Fire
Convener: Natasha Kirienko, PhD, Rice University, Houston, TX
Max Adelman, Houston Methodist Research Institute
Multi-Drug Resistant Organism Colonization is Dynamic and Associated with Adverse Outcomes in Critically Ill Patients
Poster 1
Jovan Borjan, MD Anderson Cancer Center
Resin to the Occasion: Results of Blood Culture Stewardship Efforts During a Global Blood Culture Bottle Shortage at a Comprehensive Cancer Center
Poster 2
Eric Engstrom, Baylor College of Medicine
Culture Positive Pneumococcal Pneumonia Requiring Hospital Admission from 2017-2022 at Eight US Children’s Hospitals
Poster 3
Luisannys Lozada Pinto, Houston Methodist Research Institute
Previously Unrecognized Candida auris Gut Colonization in Critically Ill Patients
Poster 4
Katia Quintanilla, Baylor College of Medicine
A Staphylococcus aureus Mutant with Increased Staphyloxanthin Production Resists Phage K Killing
Poster 5
Aditi Ranade, Pennsylvania State University
IS1 Mediated Chromosomal Amplifications are an Adaptive Strategy in E.coli B: A Polymyxin B Resistance Case Study
Poster 6
12:45-1:45 Poster Session, Poster #s 1-24
Session 4 In Memoriam of Arnold S. Bayer, MD, UCLA & The Lundquist Institute for Biomedical Innovation
Conveners: Adriana Rosato, PhD, Tufts University, Boston, MA Truc T. Tran, PharmD, Houston Methodist and Weill Cornell Medical College, Houston, TX
1:45-2:05 Phage-Encoded Virulence Factor Gp05 is Critical for Persistent MRSA Endovascular Infection
Yan Xiong, MD, PhD
The Lundquist Institute, Torrance, CA
2:05-2:25 Insights into the Interaction of MRSA with the Human Host
Victor Torres, PhD, St. Jude Children’s Research Hospital, Memphis, TN
2:25-2:45 Management of Endocarditis in the 21st Century
Vance Fowler, MD, MHS, Antibacterial Resistance Leadership Group (ARLG)
2:45-3:15 Networking Break
Session 5 NIH Antimicrobial Resistance Leadership Group (ARLG) Early-stage investigators
Conveners: Anthony Harris, University of Maryland
David van Duin, University of North Carolina Chapel Hill
3:15-3:30 BADLOCK: A Rapid, Paper-based Diagnostic for Resistant Bacterial Infection
David Roach, MD
Harvard University
3:30-3:45 Anti-Anaerobic Antibiotics and Infections in the Burn Intensive Care Unit
Natalie Mackow, MD, University of North Carolina Chapel Hill
3:45-4:00 Opening the DOOR to Improved Clinical Trial Endpoints
Jessica Howard-Anderson, MD, MSc, Emory University
4:00-4:15 Microbiota Therapies for MDRO Colonization: Challenges and Insights Across High-Risk Settings
Michael Woodworth, MD, MSc, Emory University
4:15-4:30 Break
Session 6 Selected Abstracts
Convener: Sam Shelburne, MD, PhD, MD Anderson Cancer Center, Houston, TX
Chetna Dureja, PhD, Texas A&M Health, Houston, TX
4:30-4:45 BamA Mutations Potentiate Antibiotics Activity in Escherichia Coli.
Loveth Iwuala, University of Oklahoma
4:45-5:00 Gut Microbiome Dynamics Reveal Enterococcus Species as Markers of AMR Pathogen Colonization and Dysbiosis
Hossaena Ayele, MSc, University of Texas Health Science Center, Houston
5:00-5:15 Characterization of Risk Factors Contributing to Recurrent Enterobacterales Bacteremia
William Shropshire, MPH, PhD, University of Texas MD Anderson Cancer Center
5:15-6:00 Reception & Networking-Event Hall
6:00-7:30 Documentary Screening with Michael Graziano, filmmaker -Auditorium
Introduction, Cesar Arias, Houston Methodist Research Institute
6:05-6:25 Holobiome: Maddie’s Transplant
6:30-6:50 Holobiome: Bradley’s Burden
6:50-7:30 Panel Discussion
Day 2 – Thursday, January 16, 2025
Translational and Clinical Aspects of Antibiotic Resistance
7:00-8:30 Registration
7:30-8:25 Career Mentoring Breakfast: AI in AMR Research-Event Hall
Todd Treangen, PhD, Rice University, Houston, TX
Christina Boucher, PhD, University of Florida, Gainesville, FL
Sanjat Kanjilal, MD, MPH, Harvard Medical School, Boston MA
Masayuki Nigo, MD, Houston Methodist Research Institute, Houston, TX and Weill Cornell Medical College
Session 7 Microbiome-Based Approaches for Targeting AMR Bacteria
Conveners: Kevin Garey, PharmD, University of Houston, Houston, TX
Hossaena Ayele, MSc, University of Texas Health Science Center, Houston
8:30-8:55 New Uses of Fecal Microbiome Transplantation
Herbert Dupont, MD, MD Anderson Cancer Center, Houston, TX
8:55-9:20 Enterococcus Colonization Impact on C. difficile Disease Severity
Taryn Eubank, PharmD, University of Houston
9:20-9:45 Enterobacterales Carriage and Infection: The Role of the Microbiome
Krishna Rao, MD, University of Michigan, Ann Arbor, MI
9:45-10:15 Vendor Show and Networking-Pre-function and Event Hall
Session 8 T32 Trainee Symposium: Texas Medical Center Training Program on Antimicrobial Resistance (TP-AMR), Emory Training Program on Antimicrobial Resistance, University of Pittsburgh Training Program on Antimicrobial Resistance
Conveners: Mina Henes, Emory University, Atlanta, GA
Nathan Raabe, University of Pittsburgh, Pittsburgh, PA
10:15-10:30 Genetic Basis of Cefiderocol Heteroresistance in Pseudomonas aeruginosa
Alex Kang, PhD, Houston Methodist Research Institute, Houston, TX
10:30-10:45 Mechanisms and Consequences of PasTI-mediated Bacterial Stress Resistance and Persistence
Tayor Blackburn, Emory University, Atlanta,
10:45 – 11:00 Host-Pathogen Interactions of Antibiotic-Resistant Klebsiella Pneumoniae
Nathalie Chen, University of Pittsburgh, Pittsburgh, PA
11:00 – 11:15 Antifungal Resistance and Persistence of Candida Species in Catheter-Associated Urinary Tract Infections
Shane Cristy, University of Texas Health Science Center Houston
Convener: Natasha Kirienko, PhD, Rice University, Houston, TX
11:15-12:00 Keynote Lecture
A Pharmacological View of Antibiotic Discovery
David Andes, PhD
University of Wisconsin, Madison, WI
12:00-2:10 Lunch/Rapid Fire/Poster Session-Event Hall
12:00-12:40 Lunch
12:40-1:10 Rapid Fire
Convener: Kara Hood, PhD, Houston Methodist Research Institute
Elizabeth Barrois, Baylor College of Medicine
Imacidin: A Natural Taxa-Specific Antibiotic Inhibitor of Cell Wall Biosynthesis
Poster 26
Yanhan Deng, Rice University
Role of R Pyocins in the Predominance of Pseudomonas aeruginosa Sequence Types and Their Potential in Treating MDR P. aeruginosa Infections
Poster 27
Mary North Jones, Baylor College of Medicine
Contemporary Trends in Candidemia: Species, Antifungal Resistance, and Mortality
Poster 29
Thomas Lavoie, University of Rhode Island
Comparing Crude Mortality of Ceftolozane-tazobactam and Ceftazidime-avibactam Among Inpatients in the National Veterans Affairs Healthcare System with Pseudomonas aeruginosa
Poster 30
Kaihei Masuda, University of Texas Medical Branch Galveston
A Single Center Review of Sulbactam-Durlobactam for the Treatment of Serious Acinetobacter Baumannii Infections
Poster 31
1:10-2:10 Poster Session, Poster #s 26-50
Session 9
Conveners: Cesar A. Arias MD, PhD, Houston Methodist Research Institute and Weill Cornell Medical College, Houston, TX
2:10-3:00 Challenging Clinical Cases in Antimicrobial Resistance
William R. Miller, MD, Houston Methodist Research Institute
Masayuki Nigo, MD, Houston Methodist Research Institute, Houston, TX, and Weill Cornell Medical College
Pranita Tamma, MD, MPH, Johns Hopkins University
David van Duin, MD, PhD, FIDSA, FAST, University of North Carolina
3:00-3:10 Break
Session 10 NIH Antimicrobial Resistance Leadership Group
Clinical Research in Antimicrobial Resistance
Conveners: William R. Miller, MD, Houston Methodist Research Institute
Anthony Harris, MD, MPH, University of Maryland
3:10-3:25 Pneumonia Direct Pilot
Kimberly Hanson, MD, MHS, University of Utah and ARUP Laboratories
3:25-3:40 PHAGE Trial
Pranita Tamma, MD, MPH, Johns Hopkins University
3:40-3:55 FAST Trial
Ritu Banerjee, MD, PhD, Vanderbilt University
3:55 – 4:10 POP Study: Part 2
Michael Satlin, MD, Weill Cornell Medical College
4:10-4:30 Networking break
Session 11 Artificial Intelligence and Antimicrobial Resistance
Conveners: Todd Treangen, PhD, Rice University, Houston, TX
Rodrigo Baptista, PhD, Houston Methodist Research Institute
4:30-4:50 Computational Problems in Metagenomic Amplification
Christina Boucher, PhD, University of Florida, Gainesville, FL
4:50-5:10 Applications of Machine Learning to Support Antimicrobial Stewardship
Sanjat Kanjilal, MD, MPH, Harvard Medical School, Boston MA
5:10-5:30 Use of Machine Learning in Prediction of Clinical Outcomes of Infections Including MDR Organisms
Masayuki Nigo, MD, Houston Methodist Research Institute, Houston, TX, and Weill Cornell Medical College
Day 3-Friday, January 17, 2025
7:30-8:25 Career Mentoring Breakfast: Predicting Future Pandemics and Outbreaks-Event Hall
Blake Hanson, PhD, University of Texas Health Science Center at Houston
Lauren Stadler, PhD, Rice University
Ed Septimus, MD, Harvard Medical School
Session 12
8:30-8:35 Welcome
Ed Septimus, MD, Harvard Medical School
Convenors: Kevin Garey, PharmD, MS, University of Houston College of Pharmacy
Ed Septimus, MD, Harvard Medical School
AM Keynote Presentations
8:35-9:10 Peer Review and Advancing the Science of Stewardship
Preeti Malani, MD, University of Michigan, Ann Arbor MI
9:10-9:40 Decolonization in Long-Term Care to Address Infections, Hospitalizations, and MDROs
Susan Huang, MD, MPH, UC Irvine, Irvine, CA
9:40-10:15 Vendor Show and Networking-Pre-function and Event Hall
Session 13
Conveners: Ardath Plauche, PharmD, RN, BCPS, BCIDP, Houston Methodist Research Institute
Robert Atmar, MD, Baylor College of Medicine
10:15-10:45 Bridging Pre-Clinical PKPD Animal Models to Clinical Studies
Tomefa Asempa, PharmD, Hartford Hospital, Center for Anti-Infective Research and Development Hartford CT
10:45-11:15 Diagnostic Stewardship in the ICU
Andre Kalil, MD, University of Nebraska, Omaha, NB
1115-11:45 ID Myths Part II
Melissa Johnson, PharmD, Duke University, Durham, NC
11:45-1:25 Lunch/Rapid Fire/Poster Session-Event Hall
11:45-1210 Lunch
12:10-12:40 Rapid Fire Presentations
Convener: Ed Septimus, MD, Harvard Medical School
Caroline Black, Texas Tech University
Performing Antimicrobial Susceptibility Testing in Conditions Mimicking Host Infection Environments Influences Susceptibility Outcomes
Poster 51
Chetna Dureja, Texas A&M Health Science Center Institute of Biosciences and Technology
Vancomycin Resistance Mechanism and its Impact on Treatment Outcomes in Clostridioides difficile Infection
Poster 52
Guillermo Hoppe-Elsholz, Houston Methodist Research Institute
Molecular Analysis of Enterococcus faecalis with Reduced Susceptibility to Ampicillin Associated with a Frameshift Deletion in pbp4
Poster 53
Yanhong Li, University of Pittsburgh
Genomic and Phenotypic Characterization of Enterococcus faecalis from Infective Endocarditis
Poster 54
Denver Niles, Baylor College of Medicine
Optimizing Metagenomic Next-Generation Sequencing in Infectious Disease Testing: The Role of Laboratory Stewardship
Poster 55
Melissa Sassman, Maine Health Institute for Research
Emergence and Mechanisms of High-Level Ceftaroline Resistance in MRSA Following Carbapenem Pre-Exposure
Poster 56
12:40-1:40 Posters Session, Poster #s 51-74
Session 14
Conveners: Chase McNeil, MD, Baylor College of Medicine
Charlene Offiong, PharmD, Houston Health Department
1:40-2:15 Infection in Pediatric Transplants
Elizabeth A. Moulton, MD, Baylor College of Medicine
2:15-2:45 Antimicrobial Stewardship in Immunocompromised Adult Populations
Jovan Borjan, PharmD, MD Anderson Cancer Center, Houston TX
2:45-3:15 C. difficile in Pediatrics
Travis Carlson, PharmD, University of Texas Health Science Center, San Antonio, TX
3:15-3:45 Emerging Therapies for Clostridioides difficile infection
Kevin Garey, PharmD, MS, University of Houston
3:45 Closing Comments
Ed Septimus, MD, Harvard Medical School